abstract：:Mutations in CCR5 and CCR2b have been recently shown to affect disease progression towards AIDS. A role for these host genotypes in AIDS dementia complex (ADC) has also been postulated but remains unclear. Additionally, brain-derived envelope sequences from HIV-1 have been associated with ADC but their specific contri...

journal_title：Journal of neurovirology

authors： Smith KM,Crandall KA,Kneissl ML,Navia BA

更新日期：2000-04-01 00:00:00

abstract：:A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18...

journal_title：Journal of neurovirology

authors： Sacktor NC,Skolasky RL,Lyles RH,Esposito D,Selnes OA,McArthur JC

更新日期：2000-02-01 00:00:00

abstract：:A number of pathogenic microbes including neuroinvasive viruses, bacteria and parasites are capable of entry into the central nervous system (CNS) and cause a variety of clinical manifestations. The cellular and molecular mechanisms for the CNS invasion have been extensively studied in the last two decades. Viruses in...

journal_title：Journal of neurovirology

authors： Zhang JR,Tuomanen E

更新日期：1999-12-01 00:00:00

abstract：:The neurological manifestations of HIV infection may be in part due to alterations in the blood-brain barrier. These may be caused by structural changes in the barrier or may consist of subtle metabolic or biochemical disturbances in barrier function. In the CNS, the family of glucose transporter proteins plays a key ...

journal_title：Journal of neurovirology

authors： Mankowski JL,Queen SE,Kirstein LM,Spelman JP,Laterra J,Simpson IA,Adams RJ,Clements JE,Zink MC

更新日期：1999-12-01 00:00:00

abstract：:In the possible role for human herpesviruses (HHV) in the pathogenesis of multiple sclerosis (MS) neither clear distinction between the two variants of HHV-6, nor the involvement of HHV-7 have been described. Therefore, we quantitated HHV-6 variant specific and HHV-7 reacting antibodies in the CSF of 13 patients with ...

journal_title：Journal of neurovirology

authors： Ongrádi J,Rajda C,Maródi CL,Csiszár A,Vecsei L

更新日期：1999-10-01 00:00:00

abstract：:To determine the possible influence of satellite glial cells on restricting the spread of herpes simplex virus in the peripheral nervous system, HSV replication was studied in clonally derived cultures of satellite glial cells from adult animals. Satellite cells were purified by exploiting their close anatomical assoc...

journal_title：Journal of neurovirology

authors： Wilkinson R,Leaver C,Simmons A,Pereira RA

更新日期：1999-08-01 00:00:00

abstract：:To analyze the antigenicity of peptides derived from bovine prion protein (PrP) cDNA, we immunized rabbits with four synthetic peptides and compared the immunoreactivity of antibodies to PrPs from various species by immunoblotting and immunohistochemistry. Two of the antibodies reacted strongly with all PrPs. The othe...

journal_title：Journal of neurovirology

authors： Takahashi H,Takahashi RH,Hasegawa H,Horiuchi M,Shinagawa M,Yokoyama T,Kimura K,Haritani M,Kurata T,Nagashima K

更新日期：1999-06-01 00:00:00

abstract：:Interferon-inducible expression of major histocompatibility class I genes has previously been found to be quantitatively and functionally deficient in neurons compared to other somatic cells or other neural cell types including astrocytes. This deficiency is a key component of neuronal immunoprivilege during viral inf...

journal_title：Journal of neurovirology

authors： Massa PT,Whitney LW,Wu C,Ropka SL,Jarosinski KW

更新日期：1999-04-01 00:00:00

abstract：:Infection of C57BL/6 mice with mouse hepatitis virus strain V5A13.1 (MHV-V5A13.1) results in an acute encephalitis followed by a chronic, progressive demyelinating disease with clinical and histological similarities to the human demyelinating disease Multiple Sclerosis (MS). Studies were undertaken to evaluate the con...

journal_title：Journal of neurovirology

authors： Lane TE,Fox HS,Buchmeier MJ

更新日期：1999-02-01 00:00:00

abstract：:In order to examine the effect of HTLV-I proviral load on the pathogenesis of HAM/TSP, we measured the HTLV-I proviral load in peripheral blood mononuclear cells (PBMC) from a large number of HAM/TSP patients and asymptomatic HTLV-I carriers. To measure the proviral load, we used an accurate and reproducible quantitat...

journal_title：Journal of neurovirology

authors： Nagai M,Usuku K,Matsumoto W,Kodama D,Takenouchi N,Moritoyo T,Hashiguchi S,Ichinose M,Bangham CR,Izumo S,Osame M

更新日期：1998-12-01 00:00:00

abstract：:Herpes simplex virus (HSV) latent infection of ganglion neurons follows axoplasmic transport of HSV, probably in the form of nucleocapsid from peripheral sites of infection (e.g. footpad). This raises the possibility that latency is dependent on this particular means of presenting HSV to ganglion neurons. To investiga...

journal_title：Journal of neurovirology

authors： Hay KA,Edris WA,Gaydos A,Tenser RB

更新日期：1998-10-01 00:00:00

abstract：:HIV-1 infection results in a dementing illness affecting 20% of patients with AIDS. Several HIV-1 genes have been implicated in the pathogenesis of HIV-induced neurological disease. To search for distinct HIV-1 sequences associated with the development of dementia, brain-derived tat, env, and pol sequences were examin...

journal_title：Journal of neurovirology

authors： Bratanich AC,Liu C,McArthur JC,Fudyk T,Glass JD,Mittoo S,Klassen GA,Power C

更新日期：1998-08-01 00:00:00

abstract：:Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein-Bar...

journal_title：Journal of neurovirology

authors： Portolani M,Sabbatini AM,Meacci M,Pietrosemoli P,Cermelli C,Lunghi P,Golinelli F,Stacca R

更新日期：1998-08-01 00:00:00

abstract：:A neuroinvasive/neuropathogenic SIV variant termed SIVmac182 was previously isolated and characterized (Watry et al, 1994). This neuroinvasive strain was derived from the uncloned strain SIVmac251 through serial animal passage of infected microglia, unlike previously reported neurovirulent strains. Importantly, the vi...

journal_title：Journal of neurovirology

authors： Strelow LI,Watry DD,Fox HS,Nelson JA

更新日期：1998-06-01 00:00:00

abstract：:A recombinant adenovirus vector bearing the IL-4 gene (AD-IL-4) was used to infect rat glioma C6 cells in culture at multiplicity of infections (MOI) from 50 to 1800. C6 cell proliferation was not altered significantly by adenoviral infection. However, IL-4 production increased in a dose-dependent manner. To ascertain...

journal_title：Journal of neurovirology

authors： Wei MX,Li F,Ono Y,Gauldie J,Chiocca EA

更新日期：1998-04-01 00:00:00

abstract：:Maedi Visna Virus (MVV) is a prototypic lentivirus that causes infection only in cells of macrophage lineage, unlike the primate lentiviruses which infect both CD4+ T lymphocytes and macrophages. In primates, the earliest viral invasion is associated with the ability of the virus to infect and activate T cells which c...

journal_title：Journal of neurovirology

authors： Chebloune Y,Karr BM,Raghavan R,Singh DK,Leung K,Sheffer D,Pinson D,Foresman L,Narayan O

更新日期：1998-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infections are common and severe complications of HIV infection. The virus involves the nervous system, causing encephalitis, polyradiculomyelitis and peripheral neuropathies. Due to their limited sensitivity, traditional virological approaches, such as virus isolation or antigen detection in the...

journal_title：Journal of neurovirology

authors： Cinque P,Cleator GM,Weber T,Monteyne P,Sindic C,Gerna G,van Loon AM,Klapper PE

更新日期：1998-02-01 00:00:00

abstract：:We examined murine hepatitis virus strain A59 (MHV-A59)-induced demyelinating disease in C57BL/6 mice which had previously been thymectomized at 25 days of age. Demyelination was observed in 51-96% of spinal cord quadrants examined 30 or 60 days post infection (dpi), indicating that neither an intact thymus nor thymic...

journal_title：Journal of neurovirology

authors： Sutherland RM,Chua MM,Lavi E,Weiss SR,Paterson Y

更新日期：1997-06-01 00:00:00

abstract：:The presence of antibodies reactive with Borna disease virus (BDV) in the sera of some patients with certain psychiatric illnesses has been taken as evidence that this veterinary neurotrophic virus may occasionally infect and cause psychiatric disorders in humans. In this paper, we report the results of our studies co...

journal_title：Journal of neurovirology

authors： Richt JA,Alexander RC,Herzog S,Hooper DC,Kean R,Spitsin S,Bechter K,Schüttler R,Feldmann H,Heiske A,Fu ZF,Dietzschold B,Rott R,Koprowski H

更新日期：1997-04-01 00:00:00

abstract：:Many major physiological changes occur within the rodent central nervous system (CNS) during the first few postnatal weeks. These include axonogenesis, synaptogenesis and myelination. Concomitant with CNS development over this period, there is a decrease in susceptibility to many neurotropic virus infections in that i...

journal_title：Journal of neurovirology

authors： Oliver KR,Scallan MF,Dyson H,Fazakerley JK

更新日期：1997-02-01 00:00:00

abstract：:FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-...

journal_title：Journal of neurovirology

authors： Phillips TR,Prospero-Garcia O,Wheeler DW,Wagaman PC,Lerner DL,Fox HS,Whalen LR,Bloom FE,Elder JH,Henriksen SJ

更新日期：1996-12-01 00:00:00

abstract：:We generated several lines of mice transgenic for the lacZ reporter gene under the control of an HTLV-I LTR. Two different LTR were used; one was isolated from a case of Adult T-cell Leukemia (ATL), the other from a case of Tropical Spastic Paraparesis (TSP/HAM). These LTR differed at 18 nucleotide positions. The patt...

journal_title：Journal of neurovirology

authors： Coscoy L,Gonzalez-Dunia D,Chirinian-Swan S,Brahic M,Ozden S

更新日期：1996-10-01 00:00:00

abstract：:Viral factors responsible for HSV neurovirulence in humans are still unknown. The aim of this work was to investigate the hypothesis that viral variants might contribute to the specific neurovirulence of some HSV strains. HSV-1 DNA was recovered from cerebrospinal fluid (CSF) in ten patients with HSV encephalitis (HSE...

journal_title：Journal of neurovirology

authors： Rozenberg F,Lebon P

更新日期：1996-08-01 00:00:00

abstract：:Amplification of viral nucleic acids from the cerebrospinal fluid (CSF) has considerably improved the diagnosis of several acute, subacute and chronic viral infections of the nervous system. In herpes simplex virus (HSV) encephalitis (HSE) the polymerase chain reaction (PCR) has become the method of choice for the rap...

journal_title：Journal of neurovirology

authors： Weber T,Frye S,Bodemer M,Otto M,Lüke W

更新日期：1996-06-01 00:00:00

abstract：:Nuclear factor-1 (NF-1) is a multifunctional protein that participates in both transcription and replication. NF-1 proteins exist as a family of proteins that share some common structural and functional features but also demonstrate organ and cell type specific expression. Based upon these characteristics, the family ...

journal_title：Journal of neurovirology

authors： Sumner C,Shinohara T,Durham L,Traub R,Major EO,Amemiya K

更新日期：1996-04-01 00:00:00

abstract：:Quinolinic acid (QUIN) is a tryptophan metabolite which has been found to be an excitotoxin in rats, although its toxicity in humans is unknown. QUIN has been implicated in the pathogenesis of AIDS dementia complex. This study examined the effect of QUIN on human fetal brain tissue in vitro. After at least 14 days in ...

journal_title：Journal of neurovirology

authors： Kerr SJ,Armati PJ,Brew BJ

更新日期：1995-12-01 00:00:00

abstract：:A method is described for amplification of the complete genome of the human polyomavirus JC (JCV) from progressive multifocal leukuencephalopathy (PML) brain, cerebrospinal fluid (CSF) of PML patients, and from the urine of controls without neurological disease. Efficient amplification with the 'long PCR' method is ac...

journal_title：Journal of neurovirology

authors： Agostini HT,Stoner GL

更新日期：1995-09-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) can frequently infect the central nervous system (CNS) in the setting of immunosuppression such as transplantation and infection with the human immunodeficiency virus (HIV). Our laboratory previously reported that HCMV infection of human brain aggregates preferentially infected a microglia...

journal_title：Journal of neurovirology

authors： Pulliam L,Moore D,West DC

更新日期：1995-06-01 00:00:00

abstract：:Human herpesvirus-6, the etiologic agent of exanthem subitum, is a ubiquitous virus that infects almost all children by the age of 2 years and that has previously been shown to be neuroinvasive. These characteristics suggest that human herpesvirus-6 may be important in the neuropathogenesis of acquired immune deficien...

journal_title：Journal of neurovirology

authors： Saito Y,Sharer LR,Dewhurst S,Blumberg BM,Hall CB,Epstein LG

更新日期：1995-03-01 00:00:00

abstract：:The most common complication of zoster in the elderly is postherpetic neuralgia, operationally defined as pain persisting longer than 1-2 months after rash. The cause of postherpetic neuralgia is unknown. Using polymerase chain reaction, we detected varicella zoster virus DNA in blood mononuclear cells from 11 of 51 p...

journal_title：Journal of neurovirology

authors： Mahalingam R,Wellish M,Brucklier J,Gilden DH

更新日期：1995-03-01 00:00:00